Publications

Here we built a way to turn genes up (CRISPR activation) or down (CRISPR interference) in human T cells at large scale, so we can rapidly find which genes control how strongly these cells respond to stimuli. Using this approach, we identified key genetic “switches” that shape the production of important T cell signaling molecules called cytokines and then validated how these switches reprogram T cells into more desirable functional states. Together these insights can guide the design of better T cell therapies.